Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
نویسندگان
چکیده
منابع مشابه
Influenza A virus among the hospitalized young children with acute respiratory infection. Is influenza A co infected with respiratory syncytial virus?
Background: Both influenza A virus (IAV) and respiratory syncytial virus (RSV) cause acute respiratory infection (ARI) in infants and young children. This study was conducted to determine Influenza A virus and its co infection with RSV among the hospitalized children with ARI. Methods: A total of 153 throat samples of the hospitalized young children aged between below one year and 5 years with...
متن کاملRespiratory illness associated with influenza and respiratory syncytial virus infection.
AIMS To estimate excess morbidity during periods of influenza and respiratory syncytial virus (RSV) activity. METHODS Retrospective analysis of a sentinel practice network database in active and non-active virus periods. MAIN OUTCOME MEASURES clinical diagnoses of new episodes of influenza-like illness (ILI), acute bronchitis, asthma, and otitis media. RESULTS The clinical diagnosis of IL...
متن کاملImmunogenicity and Protective Efficacy of a Dual Subunit Vaccine Against Respiratory Syncytial Virus and Influenza Virus
Respiratory syncytial virus (RSV) and influenza virus are the most significant pathogens causing respiratory tract diseases. Composite vaccines are useful in reducing the number of vaccination and confer protection against multiple infectious agents. In this study, we generated fusion of RSV G protein core fragment (amino acid residues 131 to 230) and influenza HA1 globular head domain (amino a...
متن کاملAntiviral activity of ginseng extract against respiratory syncytial virus infection
Panax ginseng has been known to have a number of immuno-modulatory effects. In this study, we investigated whether Panax Korean red ginseng extract (KRGE) has in vitro and in vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE improved the survival of human lung epithelial cells against RSV infection and inhibited RSV replication. In addition, KRGE treatment suppressed t...
متن کاملMatrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus
Increased lung levels of matrix metalloproteinase 9 (MMP9) are frequently observed during respiratory syncytial virus (RSV) infection and elevated MMP9 concentrations are associated with severe disease. However little is known of the functional role of MMP9 during lung infection with RSV. To determine whether MMP9 exerted direct antiviral potential, active MMP9 was incubated with RSV, which sho...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2017
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2017.04.070